Nature Communications (Dec 2018)

Therapeutic faecal microbiota transplantation controls intestinal inflammation through IL10 secretion by immune cells

  • Claudia Burrello,
  • Federica Garavaglia,
  • Fulvia Milena Cribiù,
  • Giulia Ercoli,
  • Gianluca Lopez,
  • Jacopo Troisi,
  • Angelo Colucci,
  • Silvia Guglietta,
  • Sara Carloni,
  • Simone Guglielmetti,
  • Valentina Taverniti,
  • Giulia Nizzoli,
  • Silvano Bosari,
  • Flavio Caprioli,
  • Maria Rescigno,
  • Federica Facciotti

DOI
https://doi.org/10.1038/s41467-018-07359-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 17

Abstract

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Faecal microbiota transplantation (FMT) is becoming a therapeutic option in several gastrointestinal disorders. Here, Burrello et al. study the immunological mechanisms by which FMT reduces colonic inflammation and initiates the restoration of intestinal homeostasis in a mouse model of colitis.