Nature Communications (Aug 2019)

Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts

  • Rajat Puri,
  • Xiu-Tang Cheng,
  • Mei-Yao Lin,
  • Ning Huang,
  • Zu-Hang Sheng

DOI
https://doi.org/10.1038/s41467-019-11636-5
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 19

Abstract

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Little is known about the pathways that maintain mitochondrial structure and function under neuronal stress conditions. Here, authors demonstrate that the Mul1-Mfn2 pathway plays a checkpoint role in maintaining mitochondrial integrity and energy maintenance by ensuring ER-mitochondrial tethering and preventing mitophagy.