Nature Communications (Jun 2022)
Cell surface glycan engineering reveals that matriglycan alone can recapitulate dystroglycan binding and function
Abstract
Matriglycan, a repeating disaccharide on α-dystroglycan, is the receptor for Lassa virus and specific extracellular matrix proteins. Here, the authors demonstrate that matriglycan, in a length-dependent tunable manner, is both necessary and sufficient for protein binding and viral infection.