mBio
(Jun 2021)
Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects
Lynda Rocheleau,
Geneviève Laroche,
Kathy Fu,
Corina M. Stewart,
Abdulhamid O. Mohamud,
Marceline Côté,
Patrick M. Giguère,
Marc-André Langlois,
Martin Pelchat
Affiliations
Lynda Rocheleau
Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Geneviève Laroche
Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Kathy Fu
Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Corina M. Stewart
Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Abdulhamid O. Mohamud
Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Marceline Côté
ORCiD Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Patrick M. Giguère
ORCiD Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Marc-André Langlois
ORCiD Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Martin Pelchat
ORCiD Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
DOI
https://doi.org/10.1128/mBio.00788-21
Journal volume & issue
Vol. 12,
no. 3
Abstract
Read online
The mutation rate and evolution of RNA viruses correlate with viral adaptation. While most mutations do not make significant contributions to viral molecular evolution, some are naturally selected and produce variants through positive selection.
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