Pigment Epithelium-Derived Factor Delays the Death of Photoreceptors in Mouse Models of Inherited Retinal Degenerations

Michel Cayouette; Sylvia B. Smith; S.Patricia Becerra; Claude Gravel

Neurobiology of Disease (Dec 1999)

Pigment Epithelium-Derived Factor Delays the Death of Photoreceptors in Mouse Models of Inherited Retinal Degenerations

Michel Cayouette,
Sylvia B. Smith,
S.Patricia Becerra,
Claude Gravel

Affiliations

Michel Cayouette: Laboratoire de Transfert de Gènes, Centre de Recherche Université Laval Robert-Giffard, 2601, de la Canardière, Beauport, Québec, Canada, G1J 2G3, Medical College of Georgia, Augusta, Georgia, 30912-2000, National Eye Institue, NIH, Building 6, Room 308, 6 Center Drive, MSC 2740, Bethesda, Maryland, 20892-2740, Faculté de Médecine, Université Laval, Cité Universitaire, Québec, Canada, G1K 7P4; Centre de Recherche Université Laval Robert-Giffard, 2601, de la Canardière, Beauport, Québec, Canada, G1J 2G3, Department of Cellular Biology and Anatomy and Ophthalmology, Medical College of Georgia, Augusta, Georgia, 30912-2000, National Eye Institue, NIH, Building 6, Room 308, 6 Center Drive, MSC 2740, Bethesda, Maryland, 20892-2740, Faculté de Médecine, Université Laval, Cité Universitaire, Québec, Canada, G1K 7P4; Centre de Recherche Université Laval Robert-Giffard, 2601, de la Canardière, Beauport, Québec, Canada, G1J 2G3, Medical College of Georgia, Augusta, Georgia, 30912-2000, Laboratory of Retinal Cell and Molecular Biology, National Eye Institue, NIH, Building 6, Room 308, 6 Center Drive, MSC 2740, Bethesda, Maryland, 20892-2740, Faculté de Médecine, Université Laval, Cité Universitaire, Québec, Canada, G1K 7P4; Centre de Recherche Université Laval Robert-Giffard, 2601, de la Canardière, Beauport, Québec, Canada, G1J 2G3, Medical College of Georgia, Augusta, Georgia, 30912-2000, National Eye Institue, NIH, Building 6, Room 308, 6 Center Drive, MSC 2740, Bethesda, Maryland, 20892-2740, Département de Psychiatrie, Faculté de Médecine, Université Laval, Cité Universitaire, Québec, Canada, G1K 7P4
Sylvia B. Smith: Laboratoire de Transfert de Gènes, Centre de Recherche Université Laval Robert-Giffard, 2601, de la Canardière, Beauport, Québec, Canada, G1J 2G3, Medical College of Georgia, Augusta, Georgia, 30912-2000, National Eye Institue, NIH, Building 6, Room 308, 6 Center Drive, MSC 2740, Bethesda, Maryland, 20892-2740, Faculté de Médecine, Université Laval, Cité Universitaire, Québec, Canada, G1K 7P4; Centre de Recherche Université Laval Robert-Giffard, 2601, de la Canardière, Beauport, Québec, Canada, G1J 2G3, Department of Cellular Biology and Anatomy and Ophthalmology, Medical College of Georgia, Augusta, Georgia, 30912-2000, National Eye Institue, NIH, Building 6, Room 308, 6 Center Drive, MSC 2740, Bethesda, Maryland, 20892-2740, Faculté de Médecine, Université Laval, Cité Universitaire, Québec, Canada, G1K 7P4; Centre de Recherche Université Laval Robert-Giffard, 2601, de la Canardière, Beauport, Québec, Canada, G1J 2G3, Medical College of Georgia, Augusta, Georgia, 30912-2000, Laboratory of Retinal Cell and Molecular Biology, National Eye Institue, NIH, Building 6, Room 308, 6 Center Drive, MSC 2740, Bethesda, Maryland, 20892-2740, Faculté de Médecine, Université Laval, Cité Universitaire, Québec, Canada, G1K 7P4; Centre de Recherche Université Laval Robert-Giffard, 2601, de la Canardière, Beauport, Québec, Canada, G1J 2G3, Medical College of Georgia, Augusta, Georgia, 30912-2000, National Eye Institue, NIH, Building 6, Room 308, 6 Center Drive, MSC 2740, Bethesda, Maryland, 20892-2740, Département de Psychiatrie, Faculté de Médecine, Université Laval, Cité Universitaire, Québec, Canada, G1K 7P4
S.Patricia Becerra: Laboratoire de Transfert de Gènes, Centre de Recherche Université Laval Robert-Giffard, 2601, de la Canardière, Beauport, Québec, Canada, G1J 2G3, Medical College of Georgia, Augusta, Georgia, 30912-2000, National Eye Institue, NIH, Building 6, Room 308, 6 Center Drive, MSC 2740, Bethesda, Maryland, 20892-2740, Faculté de Médecine, Université Laval, Cité Universitaire, Québec, Canada, G1K 7P4; Centre de Recherche Université Laval Robert-Giffard, 2601, de la Canardière, Beauport, Québec, Canada, G1J 2G3, Department of Cellular Biology and Anatomy and Ophthalmology, Medical College of Georgia, Augusta, Georgia, 30912-2000, National Eye Institue, NIH, Building 6, Room 308, 6 Center Drive, MSC 2740, Bethesda, Maryland, 20892-2740, Faculté de Médecine, Université Laval, Cité Universitaire, Québec, Canada, G1K 7P4; Centre de Recherche Université Laval Robert-Giffard, 2601, de la Canardière, Beauport, Québec, Canada, G1J 2G3, Medical College of Georgia, Augusta, Georgia, 30912-2000, Laboratory of Retinal Cell and Molecular Biology, National Eye Institue, NIH, Building 6, Room 308, 6 Center Drive, MSC 2740, Bethesda, Maryland, 20892-2740, Faculté de Médecine, Université Laval, Cité Universitaire, Québec, Canada, G1K 7P4; Centre de Recherche Université Laval Robert-Giffard, 2601, de la Canardière, Beauport, Québec, Canada, G1J 2G3, Medical College of Georgia, Augusta, Georgia, 30912-2000, National Eye Institue, NIH, Building 6, Room 308, 6 Center Drive, MSC 2740, Bethesda, Maryland, 20892-2740, Département de Psychiatrie, Faculté de Médecine, Université Laval, Cité Universitaire, Québec, Canada, G1K 7P4
Claude Gravel: Laboratoire de Transfert de Gènes, Centre de Recherche Université Laval Robert-Giffard, 2601, de la Canardière, Beauport, Québec, Canada, G1J 2G3, Medical College of Georgia, Augusta, Georgia, 30912-2000, National Eye Institue, NIH, Building 6, Room 308, 6 Center Drive, MSC 2740, Bethesda, Maryland, 20892-2740, Faculté de Médecine, Université Laval, Cité Universitaire, Québec, Canada, G1K 7P4; Centre de Recherche Université Laval Robert-Giffard, 2601, de la Canardière, Beauport, Québec, Canada, G1J 2G3, Department of Cellular Biology and Anatomy and Ophthalmology, Medical College of Georgia, Augusta, Georgia, 30912-2000, National Eye Institue, NIH, Building 6, Room 308, 6 Center Drive, MSC 2740, Bethesda, Maryland, 20892-2740, Faculté de Médecine, Université Laval, Cité Universitaire, Québec, Canada, G1K 7P4; Centre de Recherche Université Laval Robert-Giffard, 2601, de la Canardière, Beauport, Québec, Canada, G1J 2G3, Medical College of Georgia, Augusta, Georgia, 30912-2000, Laboratory of Retinal Cell and Molecular Biology, National Eye Institue, NIH, Building 6, Room 308, 6 Center Drive, MSC 2740, Bethesda, Maryland, 20892-2740, Faculté de Médecine, Université Laval, Cité Universitaire, Québec, Canada, G1K 7P4; Centre de Recherche Université Laval Robert-Giffard, 2601, de la Canardière, Beauport, Québec, Canada, G1J 2G3, Medical College of Georgia, Augusta, Georgia, 30912-2000, National Eye Institue, NIH, Building 6, Room 308, 6 Center Drive, MSC 2740, Bethesda, Maryland, 20892-2740, Département de Psychiatrie, Faculté de Médecine, Université Laval, Cité Universitaire, Québec, Canada, G1K 7P4

Journal volume & issue: Vol. 6, no. 6
pp. 523 – 532

Abstract

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Pigment epithelium-derived factor (PEDF) is a member of the serine protease inhibitor superfamily produced by retinal pigment epithelial cells in the developing and adult retina. In vitro, it induces neuronal differentiation of retinoblastoma cells and promotes survival of cerebellar granule neurons. The pedf gene is closely linked to an autosomal-dominant locus for retinitis pigmentosa, suggesting that PEDF could be a survival factor for photoreceptors. We have investigated this possibility by injecting PEDF into the eyes of homozygous retinal degeneration (rd) and retinal degeneration slow (rds) mice, two mutants displaying apoptotic photoreceptor loss. This procedure resulted in a transient delay of photoreceptor loss in the rd mouse and a reduction in apoptotic photoreceptor profiles in the rds mouse. We conclude that PEDF can act as a survival-promoting factor for photoreceptors in vivo and could potentially be useful for the treatment of photoreceptor diseases.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

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