Procr-expressing progenitor cells are responsible for murine ovulatory rupture repair of ovarian surface epithelium

Jingqiang Wang; Daisong Wang; Kun Chu; Wen Li; Yi Arial Zeng

doi:10.1038/s41467-019-12935-7

Nature Communications (Oct 2019)

Procr-expressing progenitor cells are responsible for murine ovulatory rupture repair of ovarian surface epithelium

Jingqiang Wang,
Daisong Wang,
Kun Chu,
Wen Li,
Yi Arial Zeng

Affiliations

Jingqiang Wang: State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Daisong Wang: State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Kun Chu: Reproductive Medicine Center, Changzheng Hospital, Second Military Medical University
Wen Li: Reproductive Medicine Center, Changzheng Hospital, Second Military Medical University
Yi Arial Zeng: State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-019-12935-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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The ovary is covered by a surface epithelium (OSE) and cells mediating its repair post ovulation are unclear. Here, the authors identify the Protein C Receptor (Procr) as marking progenitor cells, distinct from Lgr5+ stem cells, on the murine surface epithelium that repair the OSE post ovulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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