Longitudinal fluorescence in situ hybridization reveals cytogenetic evolution in myeloma relapsing after autologous transplantation
Maximilian Merz,
Anna Jauch,
Thomas Hielscher,
Elias K. Mai,
Anja Seckinger,
Dirk Hose,
Uta Bertsch,
Kai Neben,
Marc S. Raab,
Hans Salwender,
Igor W. Blau,
Hans-Walter Lindemann,
Ingo Schmidt-Wolf,
Christof Scheid,
Mathias Haenel,
Katja Weisel,
Hartmut Goldschmidt,
Jens Hillengass
Affiliations
Maximilian Merz
Medizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany
Anna Jauch
Institute of Human Genetics, University Heidelberg, Heidelberg, Germany
Thomas Hielscher
Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
Elias K. Mai
Medizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany
Anja Seckinger
Medizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany
Dirk Hose
Medizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany
Uta Bertsch
Medizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany
Kai Neben
Medizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany
Marc S. Raab
Medizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany;Max-Eder Research Group Experimental Therapies for Hematologic Malignancies, DKFZ, Heidelberg, Germany
Hans Salwender
Asklepios Klinik Altona, Hamburg, Germany
Igor W. Blau
Department of Internal Medicine III, Charité Campus Benjamin Franklin, Berlin, Germany
Hans-Walter Lindemann
Hämatologie/Onkologie, Kath. Krankenhaus Hagen gem. GmbH - St.-Marien-Hospital, Hagen, Germany
Ingo Schmidt-Wolf
Center for Integrated Oncology, Med. Klinik und Poliklinik III, University of Bonn, Heidelberg, Germany
Christof Scheid
Department of Internal Medicine I, University of Cologne, Heidelberg, Germany
Mathias Haenel
Klinikum Chemnitz gGmbH, Heidelberg, Germany
Katja Weisel
University Hospital of Tübingen, Heidelberg, Germany
Hartmut Goldschmidt
Medizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany;National Center for Tumor Diseases (NCT), Heidelberg, Germany
Jens Hillengass
Medizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany;Department of Radiology, German Cancer Research Center DKFZ, Heidelberg, Germany
To investigate cytogenetic evolution after upfront autologous stem cell transplantation for newly diagnosed myeloma we retrospectively analyzed fluorescence in situ hybridization results of 128 patients with paired bone marrow samples from the time of primary diagnosis and at relapse. High-risk cytogenetic abnormalities (deletion 17p and/or gain 1q21) occurred more frequently after relapse (odds ratio: 6.33; 95% confidence interval: 1.86–33.42; P
