Longitudinal fluorescence in situ hybridization reveals cytogenetic evolution in myeloma relapsing after autologous transplantation

Maximilian Merz; Anna Jauch; Thomas Hielscher; Elias K. Mai; Anja Seckinger; Dirk Hose; Uta Bertsch; Kai Neben; Marc S. Raab; Hans Salwender; Igor W. Blau; Hans-Walter Lindemann; Ingo Schmidt-Wolf; Christof Scheid; Mathias Haenel; Katja Weisel; Hartmut Goldschmidt; Jens Hillengass

doi:10.3324/haematol.2017.168005

Haematologica (Aug 2017)

Longitudinal fluorescence in situ hybridization reveals cytogenetic evolution in myeloma relapsing after autologous transplantation

Maximilian Merz,
Anna Jauch,
Thomas Hielscher,
Elias K. Mai,
Anja Seckinger,
Dirk Hose,
Uta Bertsch,
Kai Neben,
Marc S. Raab,
Hans Salwender,
Igor W. Blau,
Hans-Walter Lindemann,
Ingo Schmidt-Wolf,
Christof Scheid,
Mathias Haenel,
Katja Weisel,
Hartmut Goldschmidt,
Jens Hillengass

Affiliations

Maximilian Merz: Medizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany
Anna Jauch: Institute of Human Genetics, University Heidelberg, Heidelberg, Germany
Thomas Hielscher: Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
Elias K. Mai: Medizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany
Anja Seckinger: Medizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany
Dirk Hose: Medizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany
Uta Bertsch: Medizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany
Kai Neben: Medizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany
Marc S. Raab: Medizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany;Max-Eder Research Group Experimental Therapies for Hematologic Malignancies, DKFZ, Heidelberg, Germany
Hans Salwender: Asklepios Klinik Altona, Hamburg, Germany
Igor W. Blau: Department of Internal Medicine III, Charité Campus Benjamin Franklin, Berlin, Germany
Hans-Walter Lindemann: Hämatologie/Onkologie, Kath. Krankenhaus Hagen gem. GmbH - St.-Marien-Hospital, Hagen, Germany
Ingo Schmidt-Wolf: Center for Integrated Oncology, Med. Klinik und Poliklinik III, University of Bonn, Heidelberg, Germany
Christof Scheid: Department of Internal Medicine I, University of Cologne, Heidelberg, Germany
Mathias Haenel: Klinikum Chemnitz gGmbH, Heidelberg, Germany
Katja Weisel: University Hospital of Tübingen, Heidelberg, Germany
Hartmut Goldschmidt: Medizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany;National Center for Tumor Diseases (NCT), Heidelberg, Germany
Jens Hillengass: Medizinische Klinik V, University Hospital Heidelberg, Heidelberg, Germany;Department of Radiology, German Cancer Research Center DKFZ, Heidelberg, Germany

DOI: https://doi.org/10.3324/haematol.2017.168005
Journal volume & issue: Vol. 102, no. 8

Abstract

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To investigate cytogenetic evolution after upfront autologous stem cell transplantation for newly diagnosed myeloma we retrospectively analyzed fluorescence in situ hybridization results of 128 patients with paired bone marrow samples from the time of primary diagnosis and at relapse. High-risk cytogenetic abnormalities (deletion 17p and/or gain 1q21) occurred more frequently after relapse (odds ratio: 6.33; 95% confidence interval: 1.86–33.42; P

Published in Haematologica

ISSN: 0390-6078 (Print); 1592-8721 (Online)
Publisher: Ferrata Storti Foundation
Country of publisher: Italy
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Website: http://www.haematologica.org

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