Zdorovʹe Rebenka (Mar 2016)

Clinical Significance of Excess Lactose in the Diet (Part 2)

  • O.Ye. Abaturov,
  • A.O. Nikulina

DOI
https://doi.org/10.22141/2224-0551.2.70.2016.73840
Journal volume & issue
Vol. 11, no. 2.70
pp. 150 – 157

Abstract

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The article on the basis of published data presents the ideas about the clinical significance of excess lactose in the diet. Lactose is a specific inhibitor of β-galactoside-binding protein — galectin-9 (Gal-9) which regulates the intracellular metabolism (cell growth, inflammation, immune response, apoptosis). Lactose, competitively binding to Gal-9, prevents activation of Gal-9/TIM-3-associated signaling pathways that promotes proliferation of the T-helper 1 and 17 cells, causing the induction of inflammation. Excess lactose reduces Treg-cells representation, which have immunosuppressive action, and increases insulin resistance. Lactose inhibits the interaction of Gal-9 with immunoglobulin E and hyaluronan-binding molecule CD44 and contributes to allergic manifestations. The limitations of using exogenous lactase preparations for patho­gnomonic treatment of inflammatory and allergic diseases in children with lactase deficiency are presented.

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