Size-Controlled Preparation and Behavior Study of Phospholipid–Calcium Carbonate Hybrid Nanoparticles

Abstract

Cheng Wang, Shaoqing Chen, Lu Bao, Xuerong Liu, Fuqiang Hu, Hong Yuan College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People’s Republic of ChinaCorrespondence: Hong Yuan Email [email protected]: Calcium carbonate (CC) nanoparticles have broad biomedical utilizations, owing to their multiple intrinsic merits. However, bare CC nanoparticles do not allow for the development of multifunctional devices suitable for advanced drug delivery in cancer therapy.Methods: Phospholipid-modified phospholipid–CC hybrid nanoparticles were prepared in our study using a combination of vapor-diffusion and solvent-diffusion methods to offer optimized pharmaceutical capabilities.Results: Considering that particle size is a critical parameter that plays an important role in both in vitro and in vivo behaviors of nanoparticles, we here for the first time a present detailed protocol for the size-controlled preparation of hybrid nanoparticles, as well as analysis of the in vitro/in vivo behaviors of differently sized hybrid nanoparticles.Conclusion: Our results might significantly advance the application of this promising material in more varied fields.Keywords: calcium carbonate, phospholipid, hybrid nanoparticles

Keywords

• calcium carbonate
• phospholipid
• hybrid nanoparticles