Therapeutic Potential of Marine Peptides in Prostate Cancer: Mechanistic Insights
Salman Ahmed,
Waqas Alam,
Philippe Jeandet,
Michael Aschner,
Khalaf F. Alsharif,
Luciano Saso,
Haroon Khan
Affiliations
Salman Ahmed
Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi 75270, Pakistan
Waqas Alam
Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan
Philippe Jeandet
Research Unit “Induced Resistance and Plant Bioprotection”, Department of Biology and Biochemistry, Faculty of Sciences, University of Reims, EA 4707-USC INRAe 1488, SFR Condorcet FR CNRS 3417, P.O. Box 1039, CEDEX 02, 51687 Reims, France
Michael Aschner
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Khalaf F. Alsharif
Department of Clinical Laboratory, College of Applied Medical Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
Luciano Saso
Department of Physiology and Pharmacology, “Vittorio Erspamer” Sapienza University, 00185 Rome, Italy
Haroon Khan
Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan
Prostate cancer (PCa) is the leading cause of cancer death in men, and its treatment is commonly associated with severe adverse effects. Thus, new treatment modalities are required. In this context, natural compounds have been widely explored for their anti-PCa properties. Aquatic organisms contain numerous potential medications. Anticancer peptides are less toxic to normal cells and provide an efficacious treatment approach via multiple mechanisms, including altered cell viability, apoptosis, cell migration/invasion, suppression of angiogenesis and microtubule balance disturbances. This review sheds light on marine peptides as efficacious and safe therapeutic agents for PCa.
