A Sensitive Electrochemical Sensor Based on Sonogel-Carbon Material Enriched with Gold Nanoparticles for Melatonin Determination
Cecilia Lete,
David López-Iglesias,
Juan José García-Guzmán,
Sorina-Alexandra Leau,
Adina Elena Stanciu,
Mariana Marin,
José Maria Palacios-Santander,
Stelian Lupu,
Laura Cubillana-Aguilera
Affiliations
Cecilia Lete
Electrochemistry-Corrosion Department, Institute of Physical Chemistry “Ilie Murgulescu” of the Romanian Academy, 202 Splaiul Independentei, 022328 Bucharest, Romania
David López-Iglesias
Department of Analytical Chemistry, Faculty of Sciences, Campus de Excelencia Internacional del Mar (CEIMAR), Institute of Research on Electron Microscopy and Materials (IMEYMAT), University of Cadiz, República Saharaui, S/N. Puerto Real, 11510 Cadiz, Spain
Juan José García-Guzmán
Department of Analytical Chemistry, Faculty of Sciences, Campus de Excelencia Internacional del Mar (CEIMAR), Institute of Research on Electron Microscopy and Materials (IMEYMAT), University of Cadiz, República Saharaui, S/N. Puerto Real, 11510 Cadiz, Spain
Sorina-Alexandra Leau
Electrochemistry-Corrosion Department, Institute of Physical Chemistry “Ilie Murgulescu” of the Romanian Academy, 202 Splaiul Independentei, 022328 Bucharest, Romania
Adina Elena Stanciu
Department of Carcinogenesis and Molecular Biology, Institute of Oncology Bucharest, 252 Fundeni, 022328 Bucharest, Romania
Mariana Marin
Electrochemistry-Corrosion Department, Institute of Physical Chemistry “Ilie Murgulescu” of the Romanian Academy, 202 Splaiul Independentei, 022328 Bucharest, Romania
José Maria Palacios-Santander
Department of Analytical Chemistry, Faculty of Sciences, Campus de Excelencia Internacional del Mar (CEIMAR), Institute of Research on Electron Microscopy and Materials (IMEYMAT), University of Cadiz, República Saharaui, S/N. Puerto Real, 11510 Cadiz, Spain
Stelian Lupu
Department of Analytical Chemistry and Environmental Engineering, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, 1-7 Polizu Gh. Street, 011061 Bucharest, Romania
Laura Cubillana-Aguilera
Department of Analytical Chemistry, Faculty of Sciences, Campus de Excelencia Internacional del Mar (CEIMAR), Institute of Research on Electron Microscopy and Materials (IMEYMAT), University of Cadiz, República Saharaui, S/N. Puerto Real, 11510 Cadiz, Spain
In this work, the development of an electrochemical sensor for melatonin determination is presented. The sensor was based on Sonogel-Carbon electrode material (SNGCE) and Au nanoparticles (AuNPs). The low-cost and environmentally friendly SNGCE material was prepared by the ultrasound-assisted sonogel method. AuNPs were prepared by a chemical route and narrow size distribution was obtained. The electrochemical characterization of the SNGCE/AuNP sensor was carried out by cyclic voltammetry in the presence of a redox probe. The analytical performance of the SNGCE/AuNP sensor in terms of linear response range, repeatability, selectivity, and limit of detection was investigated. The optimized SNGCE/AuNP sensor displayed a low detection limit of 8.4 nM melatonin in synthetic samples assessed by means of the amperometry technique. The potential use of the proposed sensor in real sample analysis and the anti-matrix capability were assessed by a recovery study of melatonin detection in human peripheral blood serum with good accuracy.
