Nature Communications (Nov 2019)
The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35
- Pei Y. Liu,
- Andrew E. Tee,
- Giorgio Milazzo,
- Katherine M. Hannan,
- Jesper Maag,
- Sujanna Mondal,
- Bernard Atmadibrata,
- Nenad Bartonicek,
- Hui Peng,
- Nicholas Ho,
- Chelsea Mayoh,
- Roberto Ciaccio,
- Yuting Sun,
- Michelle J. Henderson,
- Jixuan Gao,
- Celine Everaert,
- Amy J. Hulme,
- Matthew Wong,
- Qing Lan,
- Belamy B. Cheung,
- Leming Shi,
- Jenny Y. Wang,
- Thorsten Simon,
- Matthias Fischer,
- Xu D. Zhang,
- Glenn M. Marshall,
- Murray D. Norris,
- Michelle Haber,
- Jo Vandesompele,
- Jinyan Li,
- Pieter Mestdagh,
- Ross D. Hannan,
- Marcel E. Dinger,
- Giovanni Perini,
- Tao Liu
Affiliations
- Pei Y. Liu
- Children’s Cancer Institute Australia for Medical Research
- Andrew E. Tee
- Children’s Cancer Institute Australia for Medical Research
- Giorgio Milazzo
- Department of Pharmacy and Biotechnology, University of Bologna
- Katherine M. Hannan
- Australian Cancer Research Foundation Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, The Australian National University
- Jesper Maag
- Garvan Institute of Medical Research, Sydney
- Sujanna Mondal
- Children’s Cancer Institute Australia for Medical Research
- Bernard Atmadibrata
- Children’s Cancer Institute Australia for Medical Research
- Nenad Bartonicek
- Garvan Institute of Medical Research, Sydney
- Hui Peng
- Advanced Analytics Institute, University of Technology Sydney
- Nicholas Ho
- Children’s Cancer Institute Australia for Medical Research
- Chelsea Mayoh
- Children’s Cancer Institute Australia for Medical Research
- Roberto Ciaccio
- Department of Pharmacy and Biotechnology, University of Bologna
- Yuting Sun
- Children’s Cancer Institute Australia for Medical Research
- Michelle J. Henderson
- Children’s Cancer Institute Australia for Medical Research
- Jixuan Gao
- Children’s Cancer Institute Australia for Medical Research
- Celine Everaert
- Center for Medical Genetics Ghent, Ghent University
- Amy J. Hulme
- Children’s Cancer Institute Australia for Medical Research
- Matthew Wong
- Children’s Cancer Institute Australia for Medical Research
- Qing Lan
- Department of Neurosurgery, the Second Affiliated Hospital of Soochow University
- Belamy B. Cheung
- Children’s Cancer Institute Australia for Medical Research
- Leming Shi
- State Key Laboratory of Genetic Engineering, School of Life Sciences and Human Phenome Institute, Fudan University
- Jenny Y. Wang
- Children’s Cancer Institute Australia for Medical Research
- Thorsten Simon
- Department of Pediatric Oncology and Hematology, University Hospital, University of Cologne
- Matthias Fischer
- Department of Experimental Pediatric Oncology, University Hospital, University of Cologne
- Xu D. Zhang
- School of Medicine and Public Health, Priority Research Centre for Cancer Research, University of Newcastle
- Glenn M. Marshall
- Children’s Cancer Institute Australia for Medical Research
- Murray D. Norris
- Children’s Cancer Institute Australia for Medical Research
- Michelle Haber
- Children’s Cancer Institute Australia for Medical Research
- Jo Vandesompele
- Center for Medical Genetics Ghent, Ghent University
- Jinyan Li
- Advanced Analytics Institute, University of Technology Sydney
- Pieter Mestdagh
- Center for Medical Genetics Ghent, Ghent University
- Ross D. Hannan
- Australian Cancer Research Foundation Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, The Australian National University
- Marcel E. Dinger
- Garvan Institute of Medical Research, Sydney
- Giovanni Perini
- Department of Pharmacy and Biotechnology, University of Bologna
- Tao Liu
- Children’s Cancer Institute Australia for Medical Research
- DOI
- https://doi.org/10.1038/s41467-019-12971-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
MYCN amplification is common in neuroblastomas. Here, the authors identify a long noncoding RNA, lncNB1 in these cancers and show that it promotes tumorigenesis by binding to ribosomal protein, RPL35 to enhance E2F1 and DEPDC1B protein synthesis, which phosphorylates ERK to stabilise N-Myc.
