Nature Communications (Apr 2022)

Regulated interaction of ID2 with the anaphase-promoting complex links progression through mitosis with reactivation of cell-type-specific transcription

  • Sang Bae Lee,
  • Luciano Garofano,
  • Aram Ko,
  • Fulvio D’Angelo,
  • Brulinda Frangaj,
  • Danika Sommer,
  • Qiwen Gan,
  • KyeongJin Kim,
  • Timothy Cardozo,
  • Antonio Iavarone,
  • Anna Lasorella

DOI
https://doi.org/10.1038/s41467-022-29502-2
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

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Tissue-specific transcriptional activity is silenced in mitotic cells. Here the authors reveal a general phosphorylation-dependent mechanism of recognition for the anaphase-promoting complex (APC) substrates, and show that the APC targets ID2 during the establishment of post-mitotic transcription.