Targeting fidelity of adenine and cytosine base editors in mouse embryos

Hye Kyung Lee; Michaela Willi; Shannon M. Miller; Sojung Kim; Chengyu Liu; David R. Liu; Lothar Hennighausen

doi:10.1038/s41467-018-07322-7

Nature Communications (Nov 2018)

Targeting fidelity of adenine and cytosine base editors in mouse embryos

Hye Kyung Lee,
Michaela Willi,
Shannon M. Miller,
Sojung Kim,
Chengyu Liu,
David R. Liu,
Lothar Hennighausen

Affiliations

Hye Kyung Lee: Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health
Michaela Willi: Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health
Shannon M. Miller: Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard
Sojung Kim: Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health
Chengyu Liu: Transgenic Core, National Heart, Lung, and Blood Institute, US National Institutes of Health
David R. Liu: Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard
Lothar Hennighausen: Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health

DOI: https://doi.org/10.1038/s41467-018-07322-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 6

Abstract

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Understanding the risks of bystander and off-target editing is essential for genome engineering applications. Here, the authors analyze the fidelity of adenine and cytosine base editors in vivo.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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