Nature Communications (Sep 2020)

DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4

  • Jonathan Bohlen,
  • Liza Harbrecht,
  • Saioa Blanco,
  • Katharina Clemm von Hohenberg,
  • Kai Fenzl,
  • Günter Kramer,
  • Bernd Bukau,
  • Aurelio A. Teleman

DOI
https://doi.org/10.1038/s41467-020-18452-2
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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Upon stress, translation of ATF4 is induced by reinitiating ribosomes following translation of short upstream open reading frames (uORFs). Here the authors show that translation re-initiation of ATF4 is mediated by the DENR-MCTS1 complex which acts on uORFs containing certain penultimate codons.