Антибиотики и Химиотерапия (May 2020)
Study of the Effectiveness of Drugs for the Treatment of Zoonotic Cutaneous Leishmaniasis in vivo on a Laboratory Model
Abstract
Confirmed evidence of sufficient effectiveness of monotherapy of zoonotic cutaneous leishmaniasis with meglumine antimonate and doxycycline in combination with interferon alpha 2b human recombinant (reaferon) has been obtained. Leishmania in the lesion was completely absent on day 60 of treatment with doxycycline. According to in vivo data, the combined therapy of experimental zoonotic cutaneous leishmaniasis in golden hamsters increased the effectiveness of meglumine antimonate and doxycycline by all parameters due to the addition of recombinant human interferon alpha 2b in comparison with monotherapy with the same drugs.