Comparative transcriptomics reveals highly conserved regional programs between porcine and human colonic enteric nervous system

Tao Li; Marco Morselli; Trent Su; Mulugeta Million; Muriel Larauche; Matteo Pellegrini; Yvette Taché; Pu-Qing Yuan

doi:10.1038/s42003-023-04478-x

Communications Biology (Jan 2023)

Comparative transcriptomics reveals highly conserved regional programs between porcine and human colonic enteric nervous system

Tao Li,
Marco Morselli,
Trent Su,
Mulugeta Million,
Muriel Larauche,
Matteo Pellegrini,
Yvette Taché,
Pu-Qing Yuan

Affiliations

Tao Li: CURE/Digestive Diseases Research Center, Vatche and Tamar Manoukian Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles (UCLA)
Marco Morselli: Department of Molecular, Cell, & Developmental Biology, UCLA
Trent Su: Department of Biological Chemistry, UCLA
Mulugeta Million: CURE/Digestive Diseases Research Center, Vatche and Tamar Manoukian Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles (UCLA)
Muriel Larauche: CURE/Digestive Diseases Research Center, Vatche and Tamar Manoukian Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles (UCLA)
Matteo Pellegrini: Department of Molecular, Cell, & Developmental Biology, UCLA
Yvette Taché: CURE/Digestive Diseases Research Center, Vatche and Tamar Manoukian Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles (UCLA)
Pu-Qing Yuan: CURE/Digestive Diseases Research Center, Vatche and Tamar Manoukian Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles (UCLA)

DOI: https://doi.org/10.1038/s42003-023-04478-x
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 16

Abstract

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Single-cell and bulk transcriptomic analyses between dissected components of the pig and human colonic enteric nervous system provide insight into the relevance of pig models for understanding human colonic function and neuromodulation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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