Drug-resistant Salmonella Typhi induced kidney injury with rhabdomyolysis: A case report, and literature review
Fateen Ata,
Sandy Kamil Kamal Marzouk,
Ammara Bint I. Bilal,
Adeel Ahmed Khan,
Ezzedin Ibrahim,
Mohammed Taha Mahmood Almadani
Affiliations
Fateen Ata
Department of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar; Corresponding author at: Department of internal medicine, Hamad general hospital, Doha, PO BOX 3050, Qatar.
Sandy Kamil Kamal Marzouk
College of Medicine, Qatar University, Qatar
Ammara Bint I. Bilal
Department of Radiology, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar
Adeel Ahmed Khan
Department of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar
Ezzedin Ibrahim
Department of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar
Mohammed Taha Mahmood Almadani
Department of Internal Medicine, Al Wakrah Hospital, Hamad Medical Corporation, Doha, Qatar
Salmonella Typhi (ST) is a rod-shaped gram-negative bacterium that infects humans via contaminated food or water. Humans are the only reservoirs for the bacteria. Infection usually manifests as fever, abdominal pain, and diarrhea. However, complications such as intestinal perforation, hepatosplenomegaly, and renal injury can occasionally occur. Acute kidney injury (AKI) is associated more commonly with ST than other bacteria causing gastrointestinal (GI) infections. The exact pathophysiology of AKI in ST infection is unknown. One of the rarely reported mechanisms is rhabdomyolysis. We present a similar case of resistant ST infection leading to AKI with rhabdomyolysis. This article also contains an extensive literature reviews of all reported ST bacteremia cases with AKI secondary to rhabdomyolysis.
