The Nature of Diamino Linker and Halogen Bonding Define Selectivity of Pyrrolopyrimidine-Based LIMK1 Inhibitors

• Daryl Ariawan,
• Carol Au,
• Esmeralda Paric,
• Thomas Fath,
• Yazi D. Ke,
• Michael Kassiou,
• Janet van Eersel,
• Lars M. Ittner

Affiliations

Daryl Ariawan

Dementia Research Centre, Department of Biomedical Science, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia

Carol Au

Dementia Research Centre, Department of Biomedical Science, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia

Esmeralda Paric

Dementia Research Centre, Department of Biomedical Science, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia

Thomas Fath

Dementia Research Centre, Department of Biomedical Science, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia

Yazi D. Ke

Dementia Research Centre, Department of Biomedical Science, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia

Michael Kassiou

School of Chemistry, The University of Sydney, Darlington, NSW, Australia

Janet van Eersel

Dementia Research Centre, Department of Biomedical Science, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia

Lars M. Ittner

Dementia Research Centre, Department of Biomedical Science, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia