Revista Brasileira de Ginecologia e Obstetrícia (Apr 2012)
Correlação entre a idade e a contagem dos folículos antrais em mulheres inférteis Correlation between age and antral follicles count in infertile women
Abstract
OBJETIVO: Construir um nomograma correlacionando a idade com diferentes valores dos percentis da contagem dos folículos antrais (CFA) em mulheres inférteis. MÉTODOS: Foi feito um estudo transversal de todas as pacientes atendidas, no centro de reprodução assistida Fêmina, no período de 1º de março de 2010 a 1º de outubro de 2011. As pacientes foram submetidas à ultrassonografia transvaginal do 2º ao 4º dias de seu ciclo menstrual. Foram incluídas as pacientes de 21 a 45 anos, com ciclos regulares, dois ovários íntegros, sem evidência de endocrinopatias e que assinaram o consentimento. Foram excluídas as tabagistas, portadoras de galactosemia, cistos ovarianos, com antecedente de hepatopatia, cirurgia ginecológico-ovariana e tratamento com quimioterapia ou radioterapia. Com o intuito de se verificar a correlação da CFA com a idade das pacientes, foram utilizados os percentis 5, 25, 50, 75 e 95. Com o uso dos percentis foi feita uma regressão linear que possibilitasse perceber o efeito da idade sobre a CFA. Foi utilizado como nível de significância o valor de 5% (pPURPOSE: To produce age-related nomograms for ovarian antral follicle count (AFC) in infertile women. METHODS: It was done a cross-sectional study of patients attended in the center of assisted reproduction Fêmina, from March 2010 to October 2011. The patients were submitted to transvaginal ultrasonography from day 2 to day 4 of their menstrual period. Patients included were between 21 to 45 years old, with regular menses, two healthy ovaries, without any evidence of endocrinopathies and who gave written informed consent. Patients excluded were smokers, with galactosemia or ovarian cysts, with antecedents of liver disease, ovarian surgeries or who were treated with chemotherapy or radiotherapy. In order to check the evolution of the AFC in relation to patient age, we used the 5th, 25th, 50th, 75th and 95th percentiles. Linear regression was carried out using these percentiles, permitting us to determine the effect of age on the CFA. RESULTS: A total of 172 patients with a mean age of 32.7 years were included in the trial. The male and tubal factors were the main causes of infertility, accounting for 65% of cases. The age-related nomogram for the 5th, 25th, 50th, 75th and 95th percentiles of AFC revealed that changes were best fitted by a linear function. The percentiles that showed the highest correlations were 25 (r=-0.9; p<0.001), 50 (r=-0.9; p<0.001) and 75 (r=-0.9; p<0.001). CONCLUSION: A nomogram was constructed correlating age with the different AFC percentiles in infertile women without endocrinopathies. This showed a linear pattern of decline in AFC with age in all percentiles. These nomograms could provide a reference guide for the clinician. However, future validation, with longitudinal data, still is needed.
Keywords
