Non-invasive assessment of telomere maintenance mechanisms in brain tumors

Pavithra Viswanath; Georgios Batsios; Joydeep Mukherjee; Anne Marie Gillespie; Peder E. Z. Larson; H. Artee Luchman; Joanna J. Phillips; Joseph F. Costello; Russell O. Pieper; Sabrina M. Ronen

doi:10.1038/s41467-020-20312-y

Nature Communications (Jan 2021)

Non-invasive assessment of telomere maintenance mechanisms in brain tumors

Pavithra Viswanath,
Georgios Batsios,
Joydeep Mukherjee,
Anne Marie Gillespie,
Peder E. Z. Larson,
H. Artee Luchman,
Joanna J. Phillips,
Joseph F. Costello,
Russell O. Pieper,
Sabrina M. Ronen

Affiliations

Pavithra Viswanath: Department of Radiology and Biomedical Imaging, University of California San Francisco
Georgios Batsios: Department of Radiology and Biomedical Imaging, University of California San Francisco
Joydeep Mukherjee: Department of Neurological Surgery, Helen Diller Research Center, University of California San Francisco
Anne Marie Gillespie: Department of Radiology and Biomedical Imaging, University of California San Francisco
Peder E. Z. Larson: Department of Radiology and Biomedical Imaging, University of California San Francisco
H. Artee Luchman: Department of Cell Biology and Anatomy, Arnie Charbonneau Cancer Institute and Hotchkiss Brain Institute, University of Calgary
Joanna J. Phillips: Department of Neurological Surgery, Helen Diller Research Center, University of California San Francisco
Joseph F. Costello: Department of Neurological Surgery, Helen Diller Research Center, University of California San Francisco
Russell O. Pieper: Department of Neurological Surgery, Helen Diller Research Center, University of California San Francisco
Sabrina M. Ronen: Department of Radiology and Biomedical Imaging, University of California San Francisco

DOI: https://doi.org/10.1038/s41467-020-20312-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 18

Abstract

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Telomerase expression and the alternative lengthening of telomeres pathway are hallmarks of cancer. Here, the authors show that, in primary brain tumors, these features are correlated with metabolic signatures detectable by metabolic imaging, suggesting that they can be used to non-invasively monitor telomere maintenance in brain tumours.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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