Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases

Yun Zhang; Shunbin Xiong; Bin Liu; Vinod Pant; Francis Celii; Gilda Chau; Ana C. Elizondo-Fraire; Peirong Yang; Mingjian James You; Adel K. El-Naggar; Nicholas E. Navin; Guillermina Lozano

doi:10.1038/s41467-018-06146-9

Nature Communications (Sep 2018)

Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases

Yun Zhang,
Shunbin Xiong,
Bin Liu,
Vinod Pant,
Francis Celii,
Gilda Chau,
Ana C. Elizondo-Fraire,
Peirong Yang,
Mingjian James You,
Adel K. El-Naggar,
Nicholas E. Navin,
Guillermina Lozano

Affiliations

Yun Zhang: Department of Genetics, University of Texas MD Anderson Cancer Center
Shunbin Xiong: Department of Genetics, University of Texas MD Anderson Cancer Center
Bin Liu: Department of Genetics, University of Texas MD Anderson Cancer Center
Vinod Pant: Department of Genetics, University of Texas MD Anderson Cancer Center
Francis Celii: Department of Genetics, University of Texas MD Anderson Cancer Center
Gilda Chau: Department of Genetics, University of Texas MD Anderson Cancer Center
Ana C. Elizondo-Fraire: Department of Genetics, University of Texas MD Anderson Cancer Center
Peirong Yang: Department of Genetics, University of Texas MD Anderson Cancer Center
Mingjian James You: Department of Hematopathology, University of Texas MD Anderson Cancer Center
Adel K. El-Naggar: Department of Pathology, University of Texas MD Anderson Cancer Center
Nicholas E. Navin: Department of Genetics, University of Texas MD Anderson Cancer Center
Guillermina Lozano: Department of Genetics, University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/s41467-018-06146-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

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Mutations in TP53 gene are very common in cancer development. Here the authors take advantage of murine models to show that somatic Trp53 mutations differentially drive breast cancer and evolution of metastases.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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