A parallel randomised controlled trial of the Hypoglycaemia Awareness Restoration Programme for adults with type 1 diabetes and problematic hypoglycaemia despite optimised self-care (HARPdoc)

Stephanie A. Amiel; Laura Potts; Kimberley Goldsmith; Peter Jacob; Emma L. Smith; Linda Gonder-Frederick; Simon Heller; Elena Toschi; Augustin Brooks; Dulmini Kariyawasam; Pratik Choudhary; Marietta Stadler; Helen Rogers; Mike Kendall; Nick Sevdalis; Ioannis Bakolis; Nicole de Zoysa

doi:10.1038/s41467-022-29488-x

Nature Communications (Apr 2022)

A parallel randomised controlled trial of the Hypoglycaemia Awareness Restoration Programme for adults with type 1 diabetes and problematic hypoglycaemia despite optimised self-care (HARPdoc)

Stephanie A. Amiel,
Laura Potts,
Kimberley Goldsmith,
Peter Jacob,
Emma L. Smith,
Linda Gonder-Frederick,
Simon Heller,
Elena Toschi,
Augustin Brooks,
Dulmini Kariyawasam,
Pratik Choudhary,
Marietta Stadler,
Helen Rogers,
Mike Kendall,
Nick Sevdalis,
Ioannis Bakolis,
Nicole de Zoysa

Affiliations

Stephanie A. Amiel: King’s College London
Laura Potts: Department of Biostatistics & Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
Kimberley Goldsmith: Department of Biostatistics & Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
Peter Jacob: King’s College London
Emma L. Smith: Department of Diabetes, King’s College Hospital NHS Foundation Trust
Linda Gonder-Frederick: University of Virginia School of Medicine
Simon Heller: University of Sheffield
Elena Toschi: Joslin Diabetes Center, Harvard Medical School
Augustin Brooks: University Hospitals Dorset NHS Foundation Trust
Dulmini Kariyawasam: Department of Diabetes and Endocrinology, Guy’s and St Thomas’ Hospital NHS Foundation Trust
Pratik Choudhary: King’s College London
Marietta Stadler: King’s College London
Helen Rogers: Department of Diabetes, King’s College Hospital NHS Foundation Trust
Mike Kendall: HARPdoc Patient Group, Department of Diabetes, King’s College London
Nick Sevdalis: Centre for Implementation Science, King’s College London
Ioannis Bakolis: Department of Biostatistics & Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
Nicole de Zoysa: Department of Diabetes, King’s College Hospital NHS Foundation Trust

DOI: https://doi.org/10.1038/s41467-022-29488-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

Read online

Impaired awareness of hypoglycaemia (IAH) is a risk for severe hypoglycaemia in insulin treatment of type 1 diabetes (T1D). Here the authors report that a group programme focussing on changing cognitive barriers to avoiding hypoglycaemia (HARPdoc) does not reduce severe hypoglycaemia more than a programme focussing on behaviours (BGAT) in a randomized control trial in adults with T1D and treatment-resistant IAH and severe hypoglycaemia.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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