eLife (Jan 2022)

Response to comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’

  • Alan E Mast,
  • Alisa S Wolberg,
  • David Gailani,
  • Michael R Garvin,
  • Christiane Alvarez,
  • J Izaak Miller,
  • Piet Jones,
  • Bruce Aronow,
  • Daniel Jacobson

DOI
https://doi.org/10.7554/eLife.74951
Journal volume & issue
Vol. 11

Abstract

Read online

Early in the SARS-CoV-2 pandemic, we compared transcriptome data from hospitalized COVID-19 patients and control patients without COVID-19. We found changes in procoagulant and fibrinolytic gene expression in the lungs of COVID-19 patients (Mast et al., 2021). These findings have been challenged based on issues with the samples (Fitzgerald and Jamieson, 2022). We have revisited our previous analyses in the light of this challenge and find that these new analyses support our original conclusions.

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