Response to comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’

Alan E Mast; Alisa S Wolberg; David Gailani; Michael R Garvin; Christiane Alvarez; J Izaak Miller; Piet Jones; Bruce Aronow; Daniel Jacobson

doi:10.7554/eLife.74951

eLife (Jan 2022)

Response to comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’

Alan E Mast,
Alisa S Wolberg,
David Gailani,
Michael R Garvin,
Christiane Alvarez,
J Izaak Miller,
Piet Jones,
Bruce Aronow,
Daniel Jacobson

Affiliations

Alan E Mast: ORCiD; Versiti Blood Research Institute, Department of Cell Biology Neurobiology and Anatomy Medical College of Wisconsin, Milwaukee, United States
Alisa S Wolberg: ORCiD; Department of Pathology and Laboratory Medicine and UNC Blood Research Center, Chapel Hill, United States
David Gailani: Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, United States
Michael R Garvin: ORCiD; Oak Ridge National Laboratory, Biosciences Division, Oak Ridge, United States
Christiane Alvarez: Oak Ridge National Laboratory, Biosciences Division, Oak Ridge, United States
J Izaak Miller: Oak Ridge National Laboratory, Biosciences Division, Oak Ridge, United States
Piet Jones: University of Tennessee Knoxville, The Bredesen Center for Interdisciplinary Research and Graduate Education, Knoxville, United States
Bruce Aronow: Biomedical Informatics, Cincinnati Children’s Hospital Research Foundation, University of Cincinnati, Cincinnati, United States
Daniel Jacobson: ORCiD; Oak Ridge National Laboratory, Biosciences Division, Oak Ridge, United States

DOI: https://doi.org/10.7554/eLife.74951
Journal volume & issue: Vol. 11

Abstract

Read online

Early in the SARS-CoV-2 pandemic, we compared transcriptome data from hospitalized COVID-19 patients and control patients without COVID-19. We found changes in procoagulant and fibrinolytic gene expression in the lungs of COVID-19 patients (Mast et al., 2021). These findings have been challenged based on issues with the samples (Fitzgerald and Jamieson, 2022). We have revisited our previous analyses in the light of this challenge and find that these new analyses support our original conclusions.

Published in eLife

ISSN: 2050-084X (Online)
Publisher: eLife Sciences Publications Ltd
Country of publisher: United Kingdom
LCC subjects: Medicine; Science: Biology (General)
Website: https://elifesciences.org

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Abstract

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