Impact of <i>TNFRSF1B</i> (rs3397, rs1061624 and rs1061622) and <i>IL6</i> (rs1800796, rs1800797 and rs1554606) Gene Polymorphisms on Inflammatory Response in Patients with End-Stage Kidney Disease Undergoing Dialysis
Susana Coimbra,
Susana Rocha,
Cristina Catarino,
Maria João Valente,
Petronila Rocha-Pereira,
Maria Sameiro-Faria,
José Gerardo Oliveira,
José Madureira,
João Carlos Fernandes,
Vasco Miranda,
Luís Belo,
Elsa Bronze-da-Rocha,
Alice Santos-Silva
Affiliations
Susana Coimbra
UCIBIO—Applied Molecular Biosciences Unit, Associate Laboratory, Faculdade de Farmácia da Universidade do Porto, 4050-313 Porto, Portugal
Susana Rocha
UCIBIO—Applied Molecular Biosciences Unit, Associate Laboratory, Faculdade de Farmácia da Universidade do Porto, 4050-313 Porto, Portugal
Cristina Catarino
UCIBIO—Applied Molecular Biosciences Unit, Associate Laboratory, Faculdade de Farmácia da Universidade do Porto, 4050-313 Porto, Portugal
Maria João Valente
National Food Institute, Technical University of Denmark, 2800 Kongens Lyngby, Denmark
Petronila Rocha-Pereira
UCIBIO—Applied Molecular Biosciences Unit, Associate Laboratory, Faculdade de Farmácia da Universidade do Porto, 4050-313 Porto, Portugal
Maria Sameiro-Faria
UCIBIO—Applied Molecular Biosciences Unit, Associate Laboratory, Faculdade de Farmácia da Universidade do Porto, 4050-313 Porto, Portugal
José Gerardo Oliveira
Hemodialysis Clinic of Porto (CHP), 4200-227 Porto, Portugal
José Madureira
Hemodialysis Unit of Barcelos | Nefroserve, 4750-110 Barcelos, Portugal
João Carlos Fernandes
Hemodialysis Unit of Viana do Castelo | Nefroserve, 4900-281 Viana do Castelo, Portugal
Vasco Miranda
Hemodialysis Clinic of Gondomar, 4420-086 Gondomar, Portugal
Luís Belo
UCIBIO—Applied Molecular Biosciences Unit, Associate Laboratory, Faculdade de Farmácia da Universidade do Porto, 4050-313 Porto, Portugal
Elsa Bronze-da-Rocha
UCIBIO—Applied Molecular Biosciences Unit, Associate Laboratory, Faculdade de Farmácia da Universidade do Porto, 4050-313 Porto, Portugal
Alice Santos-Silva
UCIBIO—Applied Molecular Biosciences Unit, Associate Laboratory, Faculdade de Farmácia da Universidade do Porto, 4050-313 Porto, Portugal
We aimed to study the impact of polymorphisms in the genes encoding interleukin-6 (IL6) and tumor necrosis factor receptor-2 (TNFR2), reported to be mortality risk predictors, in patients with end-stage kidney disease (ESKD) undergoing dialysis. TNFRSF1B (rs3397, rs1061624, and rs1061622) and IL6 (rs1800796, rs1800797, and rs1554606) polymorphisms were studied in patients with ESKD and controls; the genotype and allele frequencies and the associations with inflammatory and erythropoiesis markers were determined; deaths were recorded throughout the following two years. The genotype and allele frequencies for the TNFRSF1B rs3397 polymorphism were different in these patients compared to those in the controls and the global and European populations, and patients with the C allele were less common. Patients with the CC genotype for TNFRSF1B rs3397 presented higher hemoglobin and erythrocyte counts and lower TNF-α levels, suggesting a more favorable inflammatory response that seems to be associated with erythropoiesis improvement. Patients with the GG genotype for TNFRSF1B rs1061622 showed lower serum ferritin levels. None of the TNFRSF1B (rs3397, rs1061624, and rs1061622) or IL6 (rs1800796, rs1800797, and rs1554606) polymorphisms had a significant impact on the all-cause mortality rate of Portuguese patients with ESKD.
