Plantamajoside alleviates hypoxia-reoxygenation injury through integrin-linked kinase/c-Src/Akt and the mitochondrial apoptosis signaling pathways in H9c2 myocardial cells

Abstract

Highlights • It’s the first time to explore the protective effect of PMS on H9c2 cardiomyocyte hypoxia-reoxygenation injury, and to reveal its potential mechanism at the cellular level, which provides a new perspective for the prevention and treatment of MIRI in clinical practice. • The protective effect of PMS on H9c2 cardiomyocytes injured by H/R is related to stimulating the ILK/c-Src/Akt signaling pathway and inhibiting the mitochondrial apoptosis pathway. • PMS could be further developed as a drug to treat MIRI. • The result of this work will facilitate further studies on the pathophysiological mechanism of MIRI.

Keywords

• Hypoxia-reoxygenation injury
• Plantamajoside
• Network pharmacology
• ILK
• H9c2 myocardial cells