Journal of Nanotechnology (Jan 2018)

Coprecipitation Method of Synthesis, Characterization, and Cytotoxicity of Pr3+:LaF3 (CPr = 3, 7, 12, 20, 30%) Nanoparticles

  • Maksim S. Pudovkin,
  • Pavel V. Zelenikhin,
  • Victoria Shtyreva,
  • Oleg A. Morozov,
  • Darya A. Koryakovtseva,
  • Vitaly V. Pavlov,
  • Yury N. Osin,
  • Vladimir G. Evtugyn,
  • Albert A. Akhmadeev,
  • Alexey S. Nizamutdinov,
  • Vadim V. Semashko

DOI
https://doi.org/10.1155/2018/8516498
Journal volume & issue
Vol. 2018

Abstract

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The Pr3+:LaF3 (CPr = 3, 7, 12, 20, 30%) nanoparticles were characterized by means of high-resolution transmission electron microscopy, X-ray diffraction, optical spectroscopy, energy dispersive X-ray spectroscopy, dynamic light scattering, and MTT assay. It was revealed that the average diameter of all the NPs is around 14–18 nm. The hydrodynamic radius of the Pr3+:LaF3 (CPr = 7%) nanoparticles strongly depends on the medium. It was revealed that hydrodynamic radii of the Pr3+:LaF3 (CPr = 7%) nanoparticles in water, DMEM, and RPMI-1640 biological mediums were 18 ± 5, 41 ± 6, and 186 ± 8 nm, respectively. The Pr3+:LaF3 (CPr = 7%) nanoparticles were nontoxic at micromolar concentrations toward COLO-320 cell line. The lifetime curves were fitted biexponentially, and for the Pr3+:LaF3 (CPr = 7%) NPs, the luminescence lifetimes of Pr3+ ions were 480 ± 2 and 53 ± 5 nanosec.