Journal of Investigative Medicine High Impact Case Reports (Apr 2024)

Kikuchi-Fujimoto Disease: A Case Report of Prolonged Fever and Lymphadenopathy in a Young Girl

  • Ezat Mohammed Anini MD,
  • Taha Mahmoud AlBaik MD,
  • Ahmed Tayseer Ibrahim MD,
  • Nasim Afif AbuKaresh MD,
  • Maram Albandak MD,
  • Rafat Alshalaldeh MD,
  • Motaz Natsheh MD,
  • Fawzy M. Abunejma MD

DOI
https://doi.org/10.1177/23247096241246618
Journal volume & issue
Vol. 12

Abstract

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Kikuchi-Fujimoto disease (KFD) is a benign and self-limited disorder that usually presents with regional cervical lymphadenopathy and fever. We report a case of a 12-year-old female who complained of fever, night sweating, significant weight loss, and tender right cervical lymph node enlargement for 2 months. A full workup including laboratory tests and imaging studies, an excisional biopsy, and histopathological analysis were done, and the diagnosis of KFD was confirmed. The patient was treated with analgesia and oral prednisolone, resulting in good improvement. A high degree of clinical suspicion is imperative for physicians, given the rarity of the disease and the associated diagnostic challenges.