Synthesis and characterization of multifunctional graphene oxide with gamma-cyclodextrin and SPION as new nanocarriers for drug delivery

Abstract

Although oral drug delivery is the best choice, many pharmaceutical drugs such as anticancer have aromatic structure and so low solubility in water and biological fluid, which reduce the amount and rate of adsorption of these drugs and hence limits on their use in treatment. Nanoscience with unique characteristics has eliminated many of these problems. As with the use of nanoscale drug carries, many properties of drug such as solubility and half-life of the drug can be improved. Graphene and graphene oxide (GO) sheets have promising candidates to advance drug delivery platforms due to its two-dimensional structure, high chemical surface area, high chemical and physical stability, lower toxicity, and biocompatibility. One of the aims of designing drug delivery platform is to increase the effectiveness of the drug by focusing on the target tissue. Among the various type of magnetic nanoparticles, superparamagnetic iron oxide nanoparticles SPION due to its excellent magnetic properties, biocompatibility, biodegradability, and mobility in targeted area using external magnetic field, attracted a lot of attention. In the current study, we benefited from the use of graphene oxide Functionalized with γ-cyclodextrins, as carrier for SN38 and superparamagnetic iron oxide, which result shows covalent attachment of active drug molecule (SN38) to cyclodextrin-graphene oxide, increase the solubility of the drug and increase local temperature and hyperthermia following laser irradiation with a wavelength at 808 nm

Keywords

• graphene oxide
• cyclodextrin
• drug delivery
• phototherapy
• chemotherapy
• cancer