Modification of Biocorrosion and Cellular Response of Magnesium Alloy WE43 by Multiaxial Deformation
Natalia Anisimova,
Natalia Martynenko,
Keryam Novruzov,
Olga Rybalchenko,
Mikhail Kiselevskiy,
Georgy Rybalchenko,
Boris Straumal,
Gennady Salishchev,
Almagul Mansharipova,
Aigul Kabiyeva,
Maratbek Gabdullin,
Sergey Dobatkin,
Yuri Estrin
Affiliations
Natalia Anisimova
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation (N.N. Blokhin NMRCO), 115478 Moscow, Russia
Natalia Martynenko
A.A. Baikov Institute of Metallurgy and Materials Science of the RAS, 119334 Moscow, Russia
Keryam Novruzov
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation (N.N. Blokhin NMRCO), 115478 Moscow, Russia
Olga Rybalchenko
A.A. Baikov Institute of Metallurgy and Materials Science of the RAS, 119334 Moscow, Russia
Mikhail Kiselevskiy
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation (N.N. Blokhin NMRCO), 115478 Moscow, Russia
Georgy Rybalchenko
P.N. Lebedev Physical Institute of the RAS, 142432 Moscow, Russia
Boris Straumal
Laboratory of Functional Polymeric Materials, Department of Physical Metallurgy and the Physics of Strength, National University of Science and Technology “MISIS”, 119991 Moscow, Russia
Gennady Salishchev
Laboratory of Bulk Nanostructured Materials, Belgorod National Research University, 308015 Belgorod, Russia
Almagul Mansharipova
Department of Scientific and Clinical Work, Kazakh-Russian Medical University, Almaty 050000, Kazakhstan
Aigul Kabiyeva
Association of Early Career Doctors of Almaty, Almaty 050000, Kazakhstan
Maratbek Gabdullin
Kazakh British Technical University, Almaty 050000, Kazakhstan
Sergey Dobatkin
Laboratory of Functional Polymeric Materials, Department of Physical Metallurgy and the Physics of Strength, National University of Science and Technology “MISIS”, 119991 Moscow, Russia
Yuri Estrin
Department of Materials Science and Engineering, Monash University, Clayton, VIC 3800, Australia
The study shows that multiaxial deformation (MAD) treatment leads to grain refinement in magnesium alloy WE43. Compared to the initial state, the MAD-processed alloy exhibited smoother biocorrosion dynamics in a fetal bovine serum and in a complete cell growth medium. Examination by microCT demonstrated retardation of the decline in the alloy volume and the Hounsfield unit values. An attendant reduction in the rate of accumulation of the biodegradation products in the immersion medium, a less pronounced alkalization, and inhibited sedimentation of biodegradation products on the surface of the alloy were observed after MAD. These effects were accompanied with an increase in the osteogenic mesenchymal stromal cell viability on the alloy surface and in a medium containing their extracts. It is expected that the more orderly dynamics of biodegradation of the WE43 alloy after MAD and the stimulation of cell colonization will effectively promote stable osteosynthesis, making repeat implant extraction surgeries unnecessary.
