Status and function of betaDadrenoreceptors and their modification during betaDblocker treatment in patients with arterial hypertension and chronic heart failure

Abstract

Despite modern pharmacology's advances in developing new medication forms, some patients still are therapy-resistant. This review is devoted to beta-adrenoreceptor status, function, and modification during beta-adrenoblocker treatment in patients with arterial hypertension and chronic heart failure. Possible causes of beta-blocker resistance are described, including receptor-medication interaction, and beta-adrenoreceptor polymorphism.

Keywords

• beta-adrenoblockers
• beta-adrenoreceptor polymorphism
• chronic heart failure