The effect of malaria parasite infection on hematological parameters in sudanese patients

Abstract

Background: Malaria infection remains the most serious and widespread protozoan infection of humans and has been associated with different changes in hematological parameters. This study aimed to detect the effects of malaria infection on hematological parameters in Sudanese patients. Methods: This was a case–control study including 100 patients and 50 controls required from Kosti Teaching Hospital (Kosti City) from October 2, to November 11, 2020. All patients and controls were investigated for blood film for malaria, complete blood counts, and peripheral blood picture. The data were analyzed using SPSS version 16. Results: Hemoglobin (Hb) was decreased in 75% of our patients and in 10% of controls, P < 0.000. Hematocrit (HCT) was decreased in 55% of patients and in 8% of controls, P < 0.000. MCH was decreased in 33% of patients and in 12% of controls, P = 0.013. The mean corpuscular hemoglobin concentration (MCHC) was decreased in 30% of study patients and in 10% of controls, P = 0.002. The mean corpuscular volume was decreased in 34% of patients and in 8% of controls, P = 0.056. Platelet (PLTs) count was decreased in 46% of patients and 0% of controls, P < 0.000. Platelet crit (PCT) was decreased in 75% of patients and in 16% of controls, P < 0.000. Furthermore, there were differences in white blood cell (WBC) counts between malaria parasite patients and controls, P = 0.058. No significant difference in red blood cell counts was seen between malaria parasite patients and controls, P = 0.797. Conclusions: Malaria parasite infection linked to many changes in hematological parameter characterized by reduction in WBC counts, PLT counts, PCT, Hb level, HCT, MCH, and MCHC.

Keywords

• hematocrit
• hematological parameters
• hemoglobin
• malaria parasite
• mean corpuscular hemoglobin concentration
• mean corpuscular hemoglobin
• mean corpuscular volume
• pct
• red blood cells
• white blood cells