Veterinární Medicína (Aug 2019)

Mycophenolate mofetil plus prednisolone combination therapy for necrotising leukoencephalitis in a dog: long-term clinical observation, serial imaging analysis and histopathological findings

  • Su Jin An,
  • Joon Hyeok Jeon,
  • Do Hyeon Yu,
  • Joong Hyun Song,
  • Hee Chun Lee,
  • Ki Chang Lee,
  • Jung Hyang Sur,
  • Dong In Jung

DOI
https://doi.org/10.17221/116/2018-VETMED
Journal volume & issue
Vol. 64, no. 8
pp. 373 – 378

Abstract

Read online

An 8-year-old intact male mixed-breed dog presented with tetraparesis, right side head tilt, and cluster seizure-like episodes. Based on the magnetic resonance imaging and cerebrospinal fluid analysis results, meningoencephalitis of an unknown aetiology was strongly suspected. The patient survived for 963 days under mycophenolate mofetil plus prednisolone therapy and was ultimately diagnosed with necrotising leukoencephalitis. This report describes the clinical findings, the serial magnetic resonance imaging characteristics, and the histopathologic features of a case of necrotising leukoencephalitis and the long-term survival after mycophenolate mofetil plus prednisolone therapy.

Keywords