Nature Communications (Nov 2022)
Tumor factors stimulate lysosomal degradation of tumor antigens and undermine their cross-presentation in lung cancer
- Zhen Lu,
- Jinyun Chen,
- Pengfei Yu,
- Matthew J. Atherton,
- Jun Gui,
- Vivek S. Tomar,
- Justin D. Middleton,
- Neil T. Sullivan,
- Sunil Singhal,
- Subin S. George,
- Ashley G. Woolfork,
- Aalim M. Weljie,
- Tsonwin Hai,
- Evgeniy B. Eruslanov,
- Serge Y. Fuchs
Affiliations
- Zhen Lu
- Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania
- Jinyun Chen
- Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania
- Pengfei Yu
- Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania
- Matthew J. Atherton
- Department of Clinical Sciences & Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania
- Jun Gui
- Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania
- Vivek S. Tomar
- Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania
- Justin D. Middleton
- Department of Biological Chemistry and Pharmacology, The Ohio State University
- Neil T. Sullivan
- Division of Thoracic Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania
- Sunil Singhal
- Division of Thoracic Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania
- Subin S. George
- Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania
- Ashley G. Woolfork
- Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania
- Aalim M. Weljie
- Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania
- Tsonwin Hai
- Department of Biological Chemistry and Pharmacology, The Ohio State University
- Evgeniy B. Eruslanov
- Division of Thoracic Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania
- Serge Y. Fuchs
- Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania
- DOI
- https://doi.org/10.1038/s41467-022-34428-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Dendritic cells (DC) present tumour antigens to T cells but this process is defective in the tumour microenvironment. Here the authors find that downregulation of cholesterol 25-hydroxylase underlies defective cross presentation of tumour antigens.
