Antimitochindrial and antinuclear antibodies in primary biliary cholangitis

Abstract

In this work we reviewed the key antimitochondrial and antinuclear antibodies in primary biliary cholangitis – an autoimmune cholestatic disorder with destruction of intralobular biliary ductules. Since the discovery of antibodies to PDC-E2 component of cholangiocyte mitochondrial membrane, more than 60 antimitochindrial and antinuclear antibodies against various cellular components of cholangiocytes have been described to date, which have primary diagnostic and clinical value in identifying the disease progression and prognosis.

Keywords

• cholestasis
• PDC-E2
• antinuclear antibodies
• cholangiocytes
• autoimmune hepatic disorder