Communications Biology (Feb 2021)

Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection

  • Ya-Lang Huang,
  • Ming-Ting Huang,
  • Pei-Shan Sung,
  • Teh-Ying Chou,
  • Ruey-Bing Yang,
  • An-Suei Yang,
  • Chung-Ming Yu,
  • Yu-Wen Hsu,
  • Wei-Chiao Chang,
  • Shie-Liang Hsieh

DOI
https://doi.org/10.1038/s42003-021-01745-7
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 13

Abstract

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Ya-Lang Huang et al. report a mechanism for TLR3-mediated signaling after immune simulation and influenza virus infection by way of the co-receptor CLEC18A. This study found that a single amino acid change in CLEC18A(S339R) can enhance the production of type I and type III interferons to suppress viral replication, and increase mice survival rate after flu infection infection.