Department of Life Sciences, Christ University, Bengaluru, Karnataka, India-560029
Manikantan Pappuswamy
Department of Life Sciences, Christ University, Bengaluru, Karnataka, India-560029
Bader O. Almutairi
Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
Mikhlid H. Almutairi
Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
Azharuddin Daphedar
Department of Botany, Environmental Biology Laboratory, Karnatak University, Dharwad, Karnataka- 580 003, India; Department of Botany, Anjuman Arts, Science and Commerce College, Vijayapur-586 101, Karnataka. India
Aqueous extracts of Leea crispa used for producing silver nanoparticles (AgNPs) with the supplementation of the external capping substance, were determined by UV-Visible spectroscopy. The synthesized nanoparticles were examined for their antituberculosis and anticancer activities. The presence of phytoconstituents available for reducing silver ions and to form the AgNPs was confirmed using FTIR analysis. The XRD and TEM examination validated the AgNPs’ spherical particle shape and size of 15 to 85 nm and their face-centered cubic crystal form. Additionally, the FTIR spectrum revealed variation in the band values in the range 1384.0 to 3419.4 cm-1, respectively, and the EDX noted a strong band at 3 keV induced the presence of metallic silver. The AgNPs exhibited comparatively potential anti-tuberculosis activity (0.2 to 100 µg/mL) respectively. Alternatively, various doses of AgNPs, 12.5 to 400 µg/mL documented considerable activity towards the human breast cancer cell lines. The percentage of cell viability increased at 12.5g/mL and declined at 400 ng/mL concentrations of AgNPs solution. The AgNPs synthesized from L. crispa exhibited potential activity against life-threatening tuberculosis and cancer cells.
