Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion

Anastasiya Strembitska; Gwenaël Labouèbe; Alexandre Picard; Xavier P. Berney; David Tarussio; Maxime Jan; Bernard Thorens

doi:10.1038/s41467-022-33484-6

Nature Communications (Sep 2022)

Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion

Anastasiya Strembitska,
Gwenaël Labouèbe,
Alexandre Picard,
Xavier P. Berney,
David Tarussio,
Maxime Jan,
Bernard Thorens

Affiliations

Anastasiya Strembitska: Center for Integrative Genomics, University of Lausanne
Gwenaël Labouèbe: Center for Integrative Genomics, University of Lausanne
Alexandre Picard: Center for Integrative Genomics, University of Lausanne
Xavier P. Berney: Center for Integrative Genomics, University of Lausanne
David Tarussio: Center for Integrative Genomics, University of Lausanne
Maxime Jan: Bioinformatics Competence Center, University of Lausanne
Bernard Thorens: Center for Integrative Genomics, University of Lausanne

DOI: https://doi.org/10.1038/s41467-022-33484-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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During hypoglycemia, glucagon secretion is part of the mechanism needed to restore normal blood glucose levels. Here, Strembitska et al. report that sensing of hypoglycemia by AgRP neurons requires Agpat5, an enzyme which prevents fatty acids from entering the mitochondria for ATP production, ensuring correct neuronal activation and glucagon secretion.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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