Nature Communications (Feb 2020)
MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response
Abstract
Loss ofMEN1 results in an inherited multiple endocrine neoplastic type 1 syndrome. Here, the authors generate an alveolar type II cell MEN1 knockout mouse model and show that on a Kras mutant background the mice develop lung tumors with features of neuroendocrine differentiation.