Nature Communications (Feb 2020)

MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response

  • Huan Qiu,
  • Bang-Ming Jin,
  • Zhan-Feng Wang,
  • Bin Xu,
  • Qi-Fan Zheng,
  • Li Zhang,
  • Ling-Yu Zhu,
  • Shuang Shi,
  • Jun-Bo Yuan,
  • Xiao Lin,
  • Shu-Bin Gao,
  • Guang-Hui Jin

DOI
https://doi.org/10.1038/s41467-020-14614-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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Loss ofMEN1 results in an inherited multiple endocrine neoplastic type 1 syndrome. Here, the authors generate an alveolar type II cell MEN1 knockout mouse model and show that on a Kras mutant background the mice develop lung tumors with features of neuroendocrine differentiation.