Nature Communications (Nov 2019)
NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
- Evandro F. Fang,
- Yujun Hou,
- Sofie Lautrup,
- Martin Borch Jensen,
- Beimeng Yang,
- Tanima SenGupta,
- Domenica Caponio,
- Rojyar Khezri,
- Tyler G. Demarest,
- Yahyah Aman,
- David Figueroa,
- Marya Morevati,
- Ho-Joon Lee,
- Hisaya Kato,
- Henok Kassahun,
- Jong-Hyuk Lee,
- Deborah Filippelli,
- Mustafa Nazir Okur,
- Aswin Mangerich,
- Deborah L. Croteau,
- Yoshiro Maezawa,
- Costas A. Lyssiotis,
- Jun Tao,
- Koutaro Yokote,
- Tor Erik Rusten,
- Mark P. Mattson,
- Heinrich Jasper,
- Hilde Nilsen,
- Vilhelm A. Bohr
Affiliations
- Evandro F. Fang
- Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health
- Yujun Hou
- Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health
- Sofie Lautrup
- Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital
- Martin Borch Jensen
- Buck Institute for Research on Aging
- Beimeng Yang
- Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health
- Tanima SenGupta
- Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital
- Domenica Caponio
- Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital
- Rojyar Khezri
- Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital
- Tyler G. Demarest
- Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health
- Yahyah Aman
- Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital
- David Figueroa
- Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health
- Marya Morevati
- Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health
- Ho-Joon Lee
- Department of Molecular and Integrative Physiology, University of Michigan Medical School
- Hisaya Kato
- Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine
- Henok Kassahun
- Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health
- Jong-Hyuk Lee
- Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health
- Deborah Filippelli
- Molecular Toxicology Group, Department of Biology, University of Konstanz
- Mustafa Nazir Okur
- Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health
- Aswin Mangerich
- Molecular Toxicology Group, Department of Biology, University of Konstanz
- Deborah L. Croteau
- Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health
- Yoshiro Maezawa
- Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine
- Costas A. Lyssiotis
- Department of Molecular and Integrative Physiology, and Department of Internal Medicine, University of Michigan Medical School
- Jun Tao
- Department of Hypertension and Vascular Disease, the First Affiliated Hospital, Sun Yat-Sen University
- Koutaro Yokote
- Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine
- Tor Erik Rusten
- Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital
- Mark P. Mattson
- Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health
- Heinrich Jasper
- Buck Institute for Research on Aging
- Hilde Nilsen
- Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital
- Vilhelm A. Bohr
- Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-019-13172-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 18
Abstract
The molecular mechanisms of mitochondrial dysfunction in the premature ageing Werner syndrome were elusive. Here the authors show that NAD+ depletion-induced impaired mitophagy contributes to this phenomenon, shedding light on potential therapeutics.
