Nature Communications (Jul 2016)

Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons

  • Li-Wei Tung,
  • Guan-Ling Lu,
  • Yen-Hsien Lee,
  • Lung Yu,
  • Hsin-Jung Lee,
  • Emma Leishman,
  • Heather Bradshaw,
  • Ling-Ling Hwang,
  • Ming-Shiu Hung,
  • Ken Mackie,
  • Andreas Zimmer,
  • Lih-Chu Chiou

DOI
https://doi.org/10.1038/ncomms12199
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

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Stress is a major cause of relapse to cocaine seeking behaviour. Tung et al. show that orexin mediates stress-induced reinstatement of cocaine seeking behaviour in mice by endocannabinoid-dependent disinhibition in the ventral tegmental area.