Molecules (Aug 2012)
Towards Recyclable NAD(P)H Regeneration Catalysts
Abstract
Rh(III)-TsDPEN, an immobilized analog of the well-known [Cp<strong>*</strong>Rh(bpy)(H<sub>2</sub>O)]<sup>2+</sup> was evaluated as a heterogeneous, recyclable regeneration catalyst for reduced oxidoreductase cofactors [NAD(P)H]. Repeated use of this catalyst was established and the catalytic properties were initially investigated. Apparently, Rh(III)-TsDPEN is prone to severe diffusion limitations, necessitating further developments. Overall, a promising concept for chemoenzymatic redox catalysis is proposed, which may overcome some of the current limitations such as catalyst cost and incompatibility of Rh with some biocatalysts.
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