Etanercept

Abstract

Etanercept is a recombinant human receptor fusion protein that suppresses, as a contestant, the interaction of TNF-α with cell surface receptors. It received FDA approval in 1999 to be used in children older than 2 years for the treatment of juvenile idiopathic arthritis. In September 2004, it received approval for the treatment of patients with moderate to severe psoriasis who do not respond to conventional systemic treatments or for whom these therapies are contraindicated or intolerable.

Keywords

• etanercept
• tnf-α
• psoriasis