Nature Communications (May 2017)
HLA-DP84Gly constitutively presents endogenous peptides generated by the class I antigen processing pathway
- Yuki Yamashita,
- Mark Anczurowski,
- Munehide Nakatsugawa,
- Makito Tanaka,
- Yuki Kagoya,
- Ankit Sinha,
- Kenji Chamoto,
- Toshiki Ochi,
- Tingxi Guo,
- Kayoko Saso,
- Marcus O. Butler,
- Mark D. Minden,
- Thomas Kislinger,
- Naoto Hirano
Affiliations
- Yuki Yamashita
- Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network
- Mark Anczurowski
- Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network
- Munehide Nakatsugawa
- Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network
- Makito Tanaka
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Yuki Kagoya
- Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network
- Ankit Sinha
- Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network
- Kenji Chamoto
- Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network
- Toshiki Ochi
- Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network
- Tingxi Guo
- Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network
- Kayoko Saso
- Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network
- Marcus O. Butler
- Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network
- Mark D. Minden
- Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network,
- Thomas Kislinger
- Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network
- Naoto Hirano
- Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network
- DOI
- https://doi.org/10.1038/ncomms15244
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
MHC class I and II molecules generally present endogenous and exogenous peptides, respectively, through distinct mechanisms. Here, the authors show that the class II molecule HLA-DP84Glyuses both class I and II mechanisms to constitutively present peptides.
