Folia Histochemica et Cytobiologica (Jun 2010)

Correlation between hepatocyte growth factor receptor and vascular endothelial growth factor-A in breast carcinoma.

  • Aleksandra Łacko,
  • Ewelina Łata,
  • Jolanta Szelachowska,
  • Agnieszka Hałoń,
  • Elzbieta Suder,
  • Rafał Matkowski,
  • Iwona Gisterek,
  • Przemysław Biecek,
  • Jan Kornafel

DOI
https://doi.org/10.5603/4241
Journal volume & issue
Vol. 48, no. 1
pp. 78 – 83

Abstract

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The aim of the study was to evaluate the prognostic value of the vascular endothelial growth factor A (VEGF-A) and hepatocyte growth factor receptor (HGFR, c-met) expressions in homogenous group of breast cancer patients. Tumor samples were collected from 98 patients with invasive ductal breast carcinoma stage II treated with primary surgery. We have observed a strong correlation between VEGF-A and c-met. No correlations were found between VEGF-A or HGFR expressions and clinical parameters (tumor size, grade, axillary lymph node status, age), 5- and 10-years DFS or OS. Our study did not reveal any prognostic value of c-met or VEGF. In addition they are not useful to separate a patients' subgroup with poor prognosis. Unlike in other authors' studies, our patients' group is very homogenous which might tribute to obtained results.