Nature Communications (Nov 2016)

Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes

  • Hiroshi Kobayashi,
  • Song Ho Chang,
  • Daisuke Mori,
  • Shozo Itoh,
  • Makoto Hirata,
  • Yoko Hosaka,
  • Yuki Taniguchi,
  • Keita Okada,
  • Yoshifumi Mori,
  • Fumiko Yano,
  • Ung-il Chung,
  • Haruhiko Akiyama,
  • Hiroshi Kawaguchi,
  • Sakae Tanaka,
  • Taku Saito

DOI
https://doi.org/10.1038/ncomms13336
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

Read online

Rela is a transcription factor shown to have seemingly contradictory roles in anabolism and catabolism of cartilage. Here the authors find that Rela prevents chondrocyte apoptosis and that homozygous knockout causes accelerated osteoarthritis in adults, whereas heterozygous knockout suppresses osteoarthritis by maintaining wild-type effects on apoptosis but inhibiting catabolic gene expression.