Review—Prospects in Cancer Diagnosis: Exosome-Chip for Liquid Biopsy

Abstract

A liquid biopsy combined with an exosome-chip (EC) is an important detection tool for early cancer diagnosis. Exosomes have a crucial function in the exchange of information between cells and are present in biological fluids. ECs are miniaturized microfluidic devices designed to isolate, capture, and analyze exosomes for analysis of patient samples. Such devices offer on-chip detection, high-throughput analysis, and multiplex measurements. Further, these chips can integrate with electrochemical and optical detectors, and mass spectrometry enabling comprehensive studies of diseases. This review will cover the outlook on chip-based diagnostics for liquid biopsy, detection, and isolation of exosomes to support cancer diagnostics.