Hepatitis C Treatment Outcomes in Persons With HIV and Decompensated Cirrhosis Using a Collaborative Multidisciplinary HIV-Centered Approach

Edward R. Cachay MD; Alvaro Mena MD, PhD; Luis Morano MD; Laura Benitez MD; Ivana Maida MD; Carmen DE Mendoza PhD; Lucas Hill PharmD; Francesca Torriani MD; Vincente Soriano MD, PhD; W. C. Mathews MD, MSPH

doi:10.1177/23259582211024771

Journal of the International Association of Providers of AIDS Care (Jun 2021)

Hepatitis C Treatment Outcomes in Persons With HIV and Decompensated Cirrhosis Using a Collaborative Multidisciplinary HIV-Centered Approach

Edward R. Cachay MD,
Alvaro Mena MD, PhD,
Luis Morano MD,
Laura Benitez MD,
Ivana Maida MD,
Carmen DE Mendoza PhD,
Lucas Hill PharmD,
Francesca Torriani MD,
Vincente Soriano MD, PhD,
W. C. Mathews MD, MSPH,

Affiliations

Edward R. Cachay MD: Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, CA, USA
Alvaro Mena MD, PhD: U Enfermedades Infecciosas, S Medicina Interna, University Hospital of La Coruña, Spain
Luis Morano MD: Unit of Infectious Diseases, University Hospital Álvaro Cunqueiro; Vigo, Spain
Laura Benitez MD: Puerta de Hierro Research Institute and University Hospital, Madrid, Spain
Ivana Maida MD: Department of Medical, Surgical, and Experimental Sciences, University of Sassari, Sassari, Italy
Carmen DE Mendoza PhD: Puerta de Hierro Research Institute and University Hospital, Madrid, Spain
Lucas Hill PharmD: Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, CA, USA
Francesca Torriani MD: Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, CA, USA
Vincente Soriano MD, PhD: UNIR Health Sciences School & Medical Center, Madrid, Spain
W. C. Mathews MD, MSPH: Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, CA, USA

DOI: https://doi.org/10.1177/23259582211024771
Journal volume & issue: Vol. 20

Abstract

Read online

Fifty-four consecutive persons with HIV co-infected with hepatitis C virus (HCV) and liver decompensation were treated with direct-acting antivirals (DAA). The HCV treatment was delivered using a multidisciplinary HIV-coinfection model of care integrating sub-specialty services in 3 countries. Of those treated, 91% (95% confidence interval, 80.1 to 95.9) achieved sustained viral response, and only one person died during treatment. Our study provides evidence that HIV providers achieve excellent outcomes when treating patients with histories of decompensated liver disease, with characteristics similar to those studied using a multidisciplinary HIV-centered approach.

Published in Journal of the International Association of Providers of AIDS Care

ISSN: 2325-9574 (Print); 2325-9582 (Online)
Publisher: SAGE Publishing
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the genitourinary system. Urology
Website: http://journals.sagepub.com/home/jia

About the journal