Nature Communications (Aug 2022)
Organic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy
- Xiao Wang,
- Wenjing Sun,
- Huifang Shi,
- Huili Ma,
- Guowei Niu,
- Yuxin Li,
- Jiahuan Zhi,
- Xiaokang Yao,
- Zhicheng Song,
- Lei Chen,
- Shi Li,
- Guohui Yang,
- Zixing Zhou,
- Yixiao He,
- Shuli Qu,
- Min Wu,
- Zhu Zhao,
- Chengzhu Yin,
- Chongyang Lin,
- Jia Gao,
- Qiuying Li,
- Xu Zhen,
- Lin Li,
- Xiaoyuan Chen,
- Xiaogang Liu,
- Zhongfu An,
- Hongmin Chen,
- Wei Huang
Affiliations
- Xiao Wang
- Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University
- Wenjing Sun
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
- Huifang Shi
- Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University
- Huili Ma
- Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University
- Guowei Niu
- Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University
- Yuxin Li
- Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University
- Jiahuan Zhi
- Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University
- Xiaokang Yao
- Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University
- Zhicheng Song
- Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University
- Lei Chen
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
- Shi Li
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
- Guohui Yang
- Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University
- Zixing Zhou
- Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University
- Yixiao He
- Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University
- Shuli Qu
- Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University
- Min Wu
- MOE Key Laboratory of High Performance Polymer Materials and Technology, Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, and Jiangsu Key Laboratory for Nanotechnology, Nanjing University
- Zhu Zhao
- Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University
- Chengzhu Yin
- Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University
- Chongyang Lin
- Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University
- Jia Gao
- Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University
- Qiuying Li
- Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University
- Xu Zhen
- MOE Key Laboratory of High Performance Polymer Materials and Technology, Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, and Jiangsu Key Laboratory for Nanotechnology, Nanjing University
- Lin Li
- Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University
- Xiaoyuan Chen
- Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Clinical Imaging Research Centre, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore
- Xiaogang Liu
- Department of Chemistry, National University of Singapore
- Zhongfu An
- Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University
- Hongmin Chen
- State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
- Wei Huang
- Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University
- DOI
- https://doi.org/10.1038/s41467-022-32054-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 9
Abstract
Conventional X-ray-induced photodynamic therapy usually requires heavy-metal-containing inorganic scintillators and organic photosensitizers to generate singlet oxygen. Here, the authors develop an organic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy of deep tumours.
