Nature Communications (Jan 2023)

Estimation and implications of the genetic architecture of fasting and non-fasting blood glucose

  • Zhen Qiao,
  • Julia Sidorenko,
  • Joana A. Revez,
  • Angli Xue,
  • Xueling Lu,
  • Katri Pärna,
  • Harold Snieder,
  • Lifelines Cohort Study,
  • Peter M. Visscher,
  • Naomi R. Wray,
  • Loic Yengo

DOI
https://doi.org/10.1038/s41467-023-36013-1
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 11

Abstract

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Most genetic studies of glucose levels have been done on fasting samples, which can be difficult to obtain. Here, the authors identify 156 genetic loci controlling the physiological variation of glucose levels in healthy non-fasting individuals, demonstrating that the results non-fasting samples can be used to predict fasting glucose levels.